1998-1999 Wednesday Slide Conference 19
Diagnoses

 

Case 1 Contrib# OL8115  AFIP# 2648175 Brown Norway rat 

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Case 19-1. Lung. Multifocally throughout the lung, abundant macrophages, eosinophils, neutrophils and scattered foreign body or Langhans giant cells expand or replace alveoli and bronchioles.

Morphologic Diagnosis: Lung: Pneumonia, granulomatous and eosinophilic, peribronchiolar and perivascular, multifocal, moderate with perivascular edema.

Etiology: Unknown

Disease: Multifocal granulomatous pneumonia

 

Case 2 Contrib#  1971508 AFIP# 2642673 Canine (2 dogs)

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Case 19-2. Thymus. There is diffuse, marked depletion of lymphocytes and no distinction between cortical and medullary zones. Reticular stromal cells remain with few small lymphocytes.

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Case 19-2. Lymph node. There is severe lymphoid depletion here too, but subcapsular sinus, follicular, and paracortical zones can be distinguished.

Morphologic Diagnosis:

1) Thymus; lymph node: Hypoplasia, lymphoid, diffuse, severe..

2) Lymph node; thymus: Extramedullary hematopoiesis, diffuse, mild to moderate.

Comment: Some sections had no normal thymus and some had very little hypoplastic thymus.

Etiology: Probable autosomal recessive inheritance.

Disease: Severe combined immunodeficiency (SCID)

 

Case 3 Contrib#  98-7050 AFIP# 2641860 Balb/cj-Fech mouse 

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Case 19-3. Liver. There is diffuse bile duct hyperplasia. These bile ducts are often surrounded by lymphocytes and plasma cells. Scattered foci of neutrophils and intrahepatocytic brown pigment are also present.

Morphologic Diagnosis: Liver: Hyperplasia, biliary and oval cell, portal and periportal, diffuse, moderate, with mild, lymphocytic and neutrophilic, portal and periportal hepatitis, individual hepatocyte necrosis, and multifocal intracellular brown globular anisotropic pigment.

Etiology: Autosomal recessive mutation, ferrochetalase deficiency

Disease: Ferrochetalase deficiency

 

Case 4 Contrib#  AP#2489 AFIP# 2641824 Watanabe rabbit

Case 19-4. Gross Image. This closeup of mammary gland illustrates the nodularity and high fibrous connective tissue (white) content of these hyperplastic glands.

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Case 19-4. Mammary gland. Glandular acini are hyperplastic, multifocally ectatic, and separated by increased amounts of loose fibrous connective tissue stroma.

Morphologic Diagnosis: Mammary gland: Hyperplasia, ductal and stromal, diffuse, moderate to marked.

Etiology: Cyclosporine toxicity

Disease: Cyclosporine induced dys-steroidogenesis