| Bacterial |
|
|
| Tuberculosis |
Mycobacterium
tuberculosis |
Noncaseating
tubercle (granuloma prototype) a focus of epithelioid cells, rimmed by
fibroblast, lymphocytes, occasional Langhans' gant cell; caseating tubercle;
central amorphous granular debris, loss of all cellular detail; acid-fast
bacilli |
| Leprosy |
Mycobacterium
leprae |
Acid-fast
bacilli in macrophages; granulomas and epithelioid type |
| Syphilis |
Treponema
pollidum |
Gumma;
Microscopic to grossly visible lesion, enclosing wall of histiocytes; plasma
cell infitrate; center cells are necrotic without loss of celluar outline |
| Cat-scratch
disease |
Gram-negative
bacillus |
Rounded
of stellate granuloma containing central granular debris and recognizable
neutrophils; giant cells uncommon |
| Parasitic |
|
|
| Schistosomiasis |
Schistosoma
mansoni, S.haematobium, S.japonicum |
Egg
emboli; eosinophils |
| Fungal |
|
|
| |
Cryptococus
neoformans |
Organism
is yeast-like, sometimes budding; 5 to 10 mm;
large, clear capsule |
| |
Coccidioides
immitis |
Organism
appears as spherical (30-80 mm)
cyst containing endospores of 30-80 mm
each |
| Inorganic
Metals and Dusts |
| Silicosis,
berylliosis |
|
Lung
involvement; fibrosis |
| Unknown |
|
|
| Sarcoidosis |
|
Noncaseating
granuloma; gian cells (Langhans and foreign-body types); asteroids in giant
cells; occasional Schaumann's body (concentric calcific concretion); no
organisms |