| Test |
Hepatocellular
Injury |
Cholestasis |
| ALT |
> 10
x URL in most forms, for weeks |
Transient
increase to > 10 x URL with complete obstruction, falls quickly |
| ALP |
< 3
x URL in most forms |
> 3
x URL in most form, may be normal in early obstruction |
| GGT |
Usually
< 5 x URL |
Usually
> 5 x URL, may be lower in early obstruction |
| Bilirubin |
DB 50-80% |
DB 50-80%
|
| PT |
N or slightly
 in most
forms, no response to vitamin K
|
N in most
forms, may be
with prolonged obstruction, usually responds to vitamin K |
| Imaging
studies |
Normal
ducts
|
Abnormal
ducts with complete obstruction
|