| Type | Location
of Obstruction |
ALT | ALP | Bili | Example |
| Bilirubinostasis* | Hepatocyte | N | N |  |
Sepsis, sex steroids |
| Cholestatic hepatitis |
Canalicular | |
|
|
Drug-induced injury, Alpha1-antitrypsin deficiency |
| Ductular
injury |
Intrahepatic
bile ducts |
N-sli
|
|
N-sli
|
Primary biliary cirrhosis Primary sclerosing cholangitis |
| Complete
obstruction |
Extrahepatic
bile ducts |
|
|
|
Gall stones in bile duct Pancreatic head cancer |
| *Bilirubinostasis | : | excess steroid hormones (androgen, oral contraceptives, pregnancy), |
| septicemia, total parenteral nutrition and transfusion following surgery | ||
| : | only DB
|